The Detailed Information of Protein
| Protein ID: | ICDB_Pro_1574 |
|---|---|
| Protein Name: | Inositol 1;4;5-triphosphate receptor associated 1 |
| Function: | Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation. |
| Sequence: | MVKAPQSEERLAGGGKGNNSVLACGAQASWSIFGADAAEVPGTRSHSRQEAAMPHIPEDEEPPGEPQAAQSPAGQDPATTGISCSPPTIILTGDASSPEGETDKNPVNRAHSPHRRLSHRHLKVSTASLTSVDPAGHVIDLVNDQLPDISISEEDKKKNLALLEEAKLVSERFLTRRGRKSRSSPGESSPAVSPNLSPGASPASSQSNSLTVPTPPGLDVCSGPPSPLPGAPPQKGDEAEVPSPHLGESNVLKGLADRKQNDQRTLSQGRLTARSPTVEKSKEITIEQKENFDPLQRPEAIPKGPASGPGSGGKMALNSPQPGPVESELGKPLAKTAKEGNPLPRGPTQGSGGVAPQASQGKSTVGEPAGSKVGSKAELWPPTSRPPLLRGVSWDSGPEEPGPRLQKVLAKLPLAEEEKRFTGKAGSKLAKAPGLKDFQIQVQPVRMQKLTKLREEHILLRNQNLVGLKLPELSEAAEQEKGHPSELSSAIEEEESKGGLDVMPNISDVLLRKLRVHKSLPGSAPPLTEKEVENVFVQLSLAFRNDSYTLESRINQAERERNLTEENTEKELENFKASITSSASLWHHCEHRETYQKLLEDIAVLHRLAARLSSRAEMVGAVRQEKRMSKATEVMMQYVENLKRTYEKDHAELMEFKKLANQNSSRSCGPSEDGVPRTARSMSLSLGKNMPRRRVSVAVVPKFNILNLPGQSPSSSPIPSLPALSESSNGKGNPPVSSALPALLENGKTNGDPDCEASASVPTPSCLEGISQEAKARMEEEAYNKGYQEGLKKTKELQGLREEEEEQKSESPEEPEEVAETEEEEKEQRSSKLEELVHFLQVMYPKLCQHWQVIWMMAAAMLVLTVVLGLYGSHNSCVEQADGSLGKSTCSAAQRDSWWSSGLQHEQPTEQ |
| Gene Name: | IRAG1; IRAG; MRVI1 |
| Organism: | Bos taurus (Bovine) |
| Length: | 911 | PDB: |
| Ligand Binding: |
1. DICL_CP
2. DICL_Pep
|
| AlphaFoldDB: | AF-Q9N1F0-F1-model_v4.pdb |
| Binding site: | |
| Disease: | |
| Location: | Highly expressed in trachea; aorta and uterus |
| DOI ID: | 10.1038/35004606; 10.1074/jbc.m101530200; 10.1016/s0006-291x(02)02799-7; 10.1074/jbc.m507021200 |
| RefSeq: |